Multi-component synthesis of fluorophores via catalytic generation of alkynoyl intermediates

Publication date: Available online 2 July 2018Source: Drug Discovery Today: TechnologiesAuthor(s): Thomas J.J. MüllerThis account summarizes recent developments of aggregation-induced emissive and emission solvatochromic fluorophores by multicomponent reactions. Key intermediates are catalytically generated alkynoyl derivatives that are directly transformed into luminophores in a one-pot fashion. The conciseness in combination with ready access to tailored chromophore libraries makes this synthetic methodological concept superior over classical multistep syntheses.Graphical abstract
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research