In-vitro assessment of cytotoxicity, antioxidant and anti-inflammatory activities of Ficus palmata

Publication date: Available online 2 December 2017Source: Journal of Herbal MedicineAuthor(s): Vidushi Khajuria, Shilpa Gupta, Asha Bhagat, Zabeer AhmedAbstractInflammatory diseases are becoming common in ageing societies throughout the world. Clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Traditional medicines and natural products offer a viable alternative to these drugs. The present study was designed to investigate the protective effects of traditional local medicinal plant Ficus palmata from the family Moraceae. Ficus palmata Ficus palmata is used in the treatment of various diseases, e.g. gastrointestinal disorders, hypoglycemia, tumor, ulcer, diabetes, hyperlipidemia and fungal infections. The aim of this study was to observe the effect of Ficus palmata extracts, both ethanolic and hydroethanolic on lipopolysaccharide (LPS) induced inflammation in RAW 264.7 murine macrophages and the possible underlying mechanisms. In vitro study of effect of extracts showed potential inhibition of proinflammatory cytokines TNF-α and IL-6. Moreover MTT assay also confirmed the extracts don’t affect cell viability upto 100 μg/mL. Other pro-inflammatory mediators including nitric oxide (NO) and prostaglandin E2 (PGE2) are also inhibited by the extracts.Graphical abstract
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research