Improved molecular karyotyping in Glioblastoma

We examined serial resections of glioblastoma (GBM) tumor from the same patient and found low-abundance clones containing CNVs in clinically relevant loci that were not observable using bulk DNA sequencing. We discovered extensive genomic variability in this class of tumor and provide a practical approach for investigating somatic mosaicism.Graphical abstract

Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - July 10, 2018 Category: Cytology Source Type: research