In vitro and in vivo bimodal effects of docosahexaenoic acid supplements on redox status and platelet function

Publication date: Available online 14 July 2016Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Michel Lagarde, Catherine Calzada, Michel Guichardant, Evelyne VéricelAbstractDocosahexaenoic acid (DHA) is a prominent nutrient of marine lipids. Together with eicosapentaenoic acid, it is recognized as a protective molecule against atherosclerosis and thrombosis through the regulation of blood cell functions, especially platelets. Its high unsaturation index may however make it prone to peroxidation, which is usually considered as deleterious. This short review takes into consideration this possibility related to DHA concentrations both in vitro and in vivo. It is suggested that protective effects of DHA on platelet activation depend on the reduction of oxidative stress, and appear bimodal with the abolishment of such a protection when DHA is used at relatively high concentrations.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research