CRISPR genetic screens to discover host–virus interactions

Publication date: April 2018Source: Current Opinion in Virology, Volume 29Author(s): William M .McDougall, Jill M Perreira, Erin C Reynolds, Abraham L BrassViruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools has facilitated this effort by enabling host–virus screens to be undertaken in a more versatile and fidelitous manner than previously possible. Here we review the growing number of CRISPR screens which continue to increase our understanding of host–virus interactions.

Source: Current Opinion in Virology - July 10, 2018 Category: Virology Source Type: research