Pharmacodynamic assessment of diuretic efficacy and braking in a furosemide continuous infusion model

ConclusionsThere was a strong relationship between urine volume and absolute urine electrolyte excretion. Urine volume was strongly correlated to uNa:uK, giving it potential as a spot indicator of urine production during diuresis. The decrease in uNa:uK over time during the infusion is consistent with mineralocorticoid modification of urinary electrolyte excretion, supporting renin–angiotensin–aldosterone activation as a cause of diuretic braking in this model.
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research