Anti- α-glucosidase and antiglycation activities of galls from Guiera senegalensis J.F. Gmel (combretaceae)

The hypoglycemic activity ofGuiera senegalensis used in Burkinabe folk medicine has been already reported. The aim of this study was to investigate the invitro antidiabetic activity from galls ofG.senegalensis. The extracts and methanol fractions from galls ofG. senegalensis showed strong α-glucosidase inhibitory activity compared with acarbose. The ethyl acetate fraction from methanol extract (EA/ME) showed potent antiglycation activity in anin vitro assay system. The galls did not show inhibition activity against α-chymotrypsin. The α-glucosidase inhibitory activity along with its antiglycation activity may open a new perspective for the use ofG. senegalensis for the diabetic subject. The data suggests that consumption ofG senegalensis galls as an infusion or in food and pharmaceutical preparations may be useful for the management of diabetes and its complications.
Source: International Journal of Phytomedicine - Category: Science Authors: Source Type: research