Cortical Thinning Pattern of Bulbar- and Spinal-onset Amyotrophic Lateral Sclerosis: a Surface-based Morphometry Study

ConclusionThe findings suggested that bilateral motor cortex thinning presented in bulbar-onset ALS and extra-motor cortex thinning presented in spinal-onset ALS. The motor cortex thinning may be the intrinsic pathophysiological change that associated to the disease disability, and extra-motor cortex thinning may be secondary pathophysiological change that associated to disease duration.

https://www.sciencedirect.com/science/article/pii/S1001929418300300

Source: Chinese Medical Sciences Journal - July 10, 2018 Category: General Medicine Source Type: research