Analyses of HSP90α Gene Polymorphism in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

ConclusionThese findings suggest that possible role ofHSP90α polymorphism in the etiology of ARVC/D. The ‘G’ allele of HSP90α polymorphism damages the 3-D native conformations, which is required for the interaction between client proteins such as desmosomes, ryanodine receptor-2 and sodium channel leading to mislocalization of these proteins. Furthermore, loss of inhibitory interaction between HSP90α protein and Apaf-1 trigger apoptosis.
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research