Pediatric Acute Lymphoblastic Leukemia —Conquering the CNS across the Choroid Plexus

Treatment of pediatric acute lymphoblastic leukemia (ALL) has dramatically improved over the last decades, and long term survival rates have approached 90 % [1]. Given this favorable survival, reducing toxicity of treatment protocols and avoiding long term sequelae has become a major challenge for pediatric oncologists. In this regard, omitting cranial radiation in almost all patients has been a dramatic breakthrough [2,3]. However, current central nervous system (CNS) directed prophylaxis and treatment still comprises a relevant risk for neurotoxicity and impaired neurocognitive development [4 –6].

Source: Leukemia Research - July 9, 2018 Category: Hematology Authors: Martin M ärz, Svenja Meyer, Ulrike Erb, Christina Georgikou, Martin A. Horstmann, Svetlana Hetjens, Christel Weiß, Petra Fallier-Becker, Elodie Vandenhaute, Hiroshi Ishikawa, Horst Schroten, Matthias Dürken, Michael Karremann Source Type: research