5-aminolevulinic acid-mediated photodynamic therapy can target human glioma stem-like cells refractory to antineoplastic agents

Despite numerous efforts to develop novel therapies for the past decades, Glioblastoma (GBM) is characterized by extremely poor clinical outcome with the median survival shorter than two years [1 –3]. The major reasons underlying the difficulties in GBM treatment include the inability of complete surgical resection of tumor [4] as well as high resistance of GBM cells to post-surgical chemo and radiotherapies.

Source: Photodiagnosis and Photodynamic Therapy - July 7, 2018 Category: Laser Surgery Authors: Takahiro Fujishiro, Naosuke Nonoguchi, Marat Pavliukov, Naoki Ohmura, Yangtae Park, Yoshinaga Kajimoto, Toshihisa Ishikawa, Ichiro Nakano, Toshihiko Kuroiwa Source Type: research