The effect of metformin therapy on serum leptin and resistin levels in women with polycystic ovary syndrome

This study aims to investigate the effect of metformin on leptin and resistin levels in women with PCOS. Patients and methodsThis case–control study was conducted on 96 patients attending Al-Zahraa University Hospital outpatient clinic; they were classified into cases (the PCO group) (diagnosis based on the Rotterdam consensus criteria) and controls. The PCO group was further classified into two groups: Group I included obese PCO patients (32 patients) with a BMI of 30 kg/m2 or greater and group II included lean PCO patients (24 patients) with a BMI of 25 kg/m2 or less. Controls (group III) included obese (40 patients) (BMI≥30 kg/m2) non-PCO individuals with regular menstrual cycles and with no clinical or biochemical signs of hyperandrogenism; they attended the clinic for other gynecological complains. The patients and controls were subjected to the following before metformin therapy (500 mg three times daily for 6 months): history taking, physical examination, calculation of BMI of all women and waist–hip ratio (WHR), and transvaginal ultrasound. Blood samples were obtained for hormonal profile after an overnight fasting on the third day of the menstrual cycle or on the day of the first visit in anovulatory women and in women with amenorrhea, and also for FSH, LH, serum leptin, resistin, serum prolactin, TSH, E2, testosterone, dehydroepiandrosterone (DHEAS), serum progesterone, fasting insulin (FI), fasting blood glucose, and insulin resistance (IR) [The homeostatic m...
Source: Journal of Evidence-Based Women’s Health Journal Society - Category: OBGYN Tags: Original articles Source Type: research