Tricyclic antidepressants inhibit Candida albicans growth and biofilm formation

Candida albicans is a commensal yeast of the human gastrointestinal and gastrourinary tracts. In immune compromised individuals, C. albicans can cross the host's protective membranes and colonize internal organs, producing life-threatening infections. In addition, C. albicans may become an opportunistic pathogen even for healthy individuals because of its ability to form biofilms on solid surfaces, such as implanted medical devices, where they contribute to nosocomial infections [1]. The biofilm formation is a systematic, highly controlled process involving different stages.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research