Safety and efficacy of modified Jessner’s solution versus 70% glycolic acid for the treatment of melasma in different skin types: a split-face study

BackgroundThe treatment of melasma has been challenging; numerous approaches have been used with variable results. Chemical peeling is an established technique for the treatment of pigmentary imperfections.
ObjectiveThe aim of the study was to compare the efficacy and safety of glycolic acid (GA) 70% and a modified Jessner’s solution in the treatment of melasma in different skin types among a sample of Egyptian women.
Patients and methodsThirty women with a clinical diagnosis of melasma were selected. Modified Jessner’s solution and GA 70% were applied on a split-face basis at a 2-week interval for a maximum of eight sessions. Evaluation of the results was carried out by the Melasma Area and Severity Index (MASI) score at baseline, at the end of sessions, and after the follow-up period of 16 weeks. Patient satisfaction score and Global Aesthetic Improvement Scale were evaluated by a blinded clinical investigator. Side effects were recorded.
ResultsThere was a significant reduction in the total MASI score in the modified Jessner’s solution-treated side than in the GA 70%-treated side after the last session (P

Source: Journal of the Egyptian Women’s Dermatologic Society - September 1, 2014 Category: Dermatology Tags: Original articles Source Type: research