A systematic cochrane review of autogenic drainage (Ad) for airway clearance in cystic fibrosis

Cystic fibrosis (CF) is an autosomal recessive genetic condition affecting the gene that codes for the cystic fibrosis transmembrane conductance regulator (CFTR). This in turn interferes with the movement of chloride across the apical membrane of respiratory epithelial cells. Abnormal chloride transport affects the production of airway surface liquid, which disturbs the ability of the cilia to clear the airways[1]. This important physiological process (the mucociliary escalator) protects the airways and disruption of this process makes the airways vulnerable to the infections characterising CF lung disease.
Source: Paediatric Respiratory Reviews - Category: Respiratory Medicine Authors: Tags: Editorial Source Type: research