Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor

Publication date: July 2018Source: Chinese Journal of Analytical Chemistry, Volume 46, Issue 7Author(s): Zai-Hui DU, Xiang-Yang LI, Jing-Jing TIAN, Yang-Zi Zhang, Hong-Tao TIAN, Wen-Tao XUAbstractFunctional nucleic acids are natural or artificial nucleic acid sequences with specific functions and special structures. A part of metal ions are essential trace elements of human health, but excessive metal ions will be harmful to human health. The functional nucleic acids are widely used for detection of metal ions because of its advantages such as easy modification, low price, high stability and strong specificity. This paper detailed the interaction between functional nucleic acids and metal ions, mainly including cutting type, link type, metal ion-mediated base pairing, click chemistry type, conformational change type, and other types. The biosensors based on the combination of functional nucleic acid with different signal output were then introduced. Finally, the research significance and existing problems of functional nucleic acid for metal ion detection were discussed. The future development trends and applications of functional nucleic acid biosensor were prospected.Graphical AbstractIn this paper, the mechanism of functional nucleic acid and metal ions is summarized in detail, and the biosensors based on the combination of functional nucleic acid and different output signals are introduced. Finally, the foundation future research and development of metal ion function nucl...

Source: Chinese Journal of Analytical Chemistry - July 6, 2018 Category: Chemistry Source Type: research