Thermal proteome profiling in bacteria: probing protein state in vivo

In conclusion, we demonstrate that TPP can be used in bacteria to probe protein complex architecture, metabolic pathways, and intracellular drug target engagement.

Source: Molecular Systems Biology - July 6, 2018 Category: Molecular Biology Authors: Mateus, A., Bobonis, J., Kurzawa, N., Stein, F., Helm, D., Hevler, J., Typas, A., Savitski, M. M. Tags: Genome-Scale & Integrative Biology, Microbiology, Virology & Host Pathogen Interaction, Post-translational Modifications, Proteolysis & Proteomics Articles Source Type: research