Telocytes as possible precursors of PDGFRA-mutant gastrointestinal mesenchymal tumors —reply

We are pleased that Ricci et al. have provided supporting evidence for our hypothesis that the telocyte, the only CD34- and PDGFRA-positive cell of the stomach and intestines [1], is the cell of origin of inflammatory fibroid polyps (IFPs). IFPs arising sporadically or syndromically predominantly have a gain-of-function mutation within the PDGFRA gene and are CD34 and PDGFRA positive.

Source: Human Pathology - July 5, 2018 Category: Pathology Authors: Paul Manley, Jagdeep S Walia, Richard Kirsch, Robert Riddell Tags: Correspondence Source Type: research