Primary evidence of the mechanisms of action of HIV aspartyl peptidase inhibitors on Trypanosoma cruzi trypomastigote forms

Chagas disease is caused by the protozoand Trypanosoma cruzi and is a well-knownd neglected endemic disease in Latin America. This disease has also become a public health problem in North America and in many European and some Western Pacific countries because of population migration from endemic areas [1]. An estimated 7 –10 million people are chronically infected with T. cruzi and 10–14 thousand deaths per year are caused by the parasite [1].

Source: International Journal of Antimicrobial Agents - April 7, 2018 Category: Drugs & Pharmacology Authors: Leandro S. Sangenito, Rubem F.S. Menna-Barreto, Ana Carolina Oliveira, Claudia M. d'Avila-Levy, Marta H. Branquinha, Andr é L.S. Santos Source Type: research