Increased expression of CRF and CRF-receptors in dorsal striatum, hippocampus, and prefrontal cortex after the development of nicotine sensitization in rats

Nicotine dependence drives the habit of smoking, which causes a heavy load of disease and death, as smoking is one of the largest contributors to preventable morbidity and mortality (GBD 2015 Risk Factors Collaborators, 2016; World Health Organization(WHO), 2017). Inhaled nicotine reaches the brain, where it binds and activates nicotinic acetylcholine receptors (Hurst et al., 2013; Zoli et al., 2015) in several brain regions, including the mesocorticolimbic regions involved in the reward system (Picciotto and Kenny, 2013).
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Full length article Source Type: research