Depressive Symptoms and Adipokines in Women: Study of Women ’s Health Across the Nation

Major depressive disorder (MDD) and depressive symptoms have been linked to obesity, metabolic syndrome, insulin resistance, and diabetes (Everson et al., 2002; Everson-Rose et al., 2004; Golden et al., 2004), all of which are metabolic risk factors that increase risk for cardiovascular disease (CVD). A potential pathophysiologic pathway by which depression influences metabolic dysregulation is inflammation (Stewart et al., 2009; Rethorst et al., 2014). Clear associations have been reported between depression and C-reactive protein (CRP), interleukin 6 (IL-6), fibrinogen, and tumor necrosis factor alpha (TNF-a) (Maes, 1999; Miller et al., 2002; Matthews et al., 2007).

Source: Psychoneuroendocrinology - July 5, 2018 Category: Psychiatry Authors: Susan A. Everson-Rose, Cari J. Clark, Qi Wang, Hongfei Guo, Peter Mancuso, Howard M. Kravitz, Joyce T. Bromberger Source Type: research