PBC and related extrahepatic diseases

Publication date: Available online 23 May 2018Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Floreani Annarosa, Cazzagon NoraAbstractPatients with PBC have at least 60% of probability to have an autoimmune extrahepatic condition. The pathogenesis of these conditions includes a common mechanism involving both innate and adaptive immune responses targeting cholangiocytes and different extrahepatic tissues. The recent EASL guidelines recommend the management of these conditions, although detailed practical treatments have not been indicated. Autoimmune extrahepatic conditions may include: rheumatologic, endocrine, pulmonary, gastrointestinal, dermatologic diseases. This review aims to focus the most important extrahepatic autoimmune conditions associated to PBC with practical recommendation regarding diagnostic approach and management.
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research