Dendritic cell-based cancer immunotherapy for pancreatic cancer

Publication date: March 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 1Author(s): Wei Li, Xiujun Song, Huijie Yu, Manze Zhang, Fengsheng Li, Cheng Cao, Qisheng JiangAbstractPancreatic cancer (PC) is a lethal disease and remains one of the most resistant cancers to traditional therapies. New therapeutic modalities are urgently needed, particularly immunotherapy, which has shown promise in numerous animal model studies. Dendritic cell (DC)-based immunotherapy has been used in clinical trials for various cancers, including PC, because DCs are the most potent antigen-presenting cell (APC), which are capable of priming naive T cells and stimulating memory T cells to generate antigen-specific responses. In this paper, we review the preclinical and clinical efforts towards the application of DCs for PC.
Source: Arab Journal of Gastroenterology - Category: Gastroenterology Source Type: research