The value of type IV collagen immunohistochemical staining in the differential diagnosis of autoimmune subepidermal bullous diseases

In conclusion, type IV collagen IHC staining is a simple and useful diagnostic technique for the differential diagnosis of AISBDs. .042) compared with controls. The filiform papillae had partially or completely regenerated in 85.7% of cases in the test group and in 23.1% of the controls (P=0.001). Red patches with raised keratotic rims may have healed spontaneously and reappeared in constantly changing patterns that are typical for MG. This phenomenon was not observed in patients supplemented with zinc, and new atrophy areas occurred in only one case. Low-dose zinc gluconate supplementation may have a positive therapeutic effect on tongue epithelium regeneration and symptomatology in patients with MG.  in our region were consistent with those from other studies. 
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research