Differential tissue distribution of Trypanosoma cruzi during acute experimental infection: Further evidence using natural isolates

Publication date: June 2018Source: Molecular and Biochemical Parasitology, Volume 222Author(s): Mariana Strauss, Daniela A. Velázquez López, Diego M. Moya, P. Carolina Bazán, Alejandra L. Báez, H. Walter Rivarola, Patricia A. Paglini-Oliva, M. Silvina Lo PrestiAbstractIn the present work, we evaluated the effect of mixed Trypanosoma cruzi infections, studying the biological distribution of the different parasites in blood, heart and skeletal muscle during the acute phase. Albino Swiss mice were infected with different parasite strain/isolates or with a combination of them. The parasites in the different tissues were typified through specific PCR, population variability was analyzed through RFLP studies and parasitological and histopathological parameters were evaluated. We found a predominance of TcII and TcVI in all tissues samples respect to TcV and different parasite populations were found in circulation and in the tissues from the same host. These results verify the distribution of parasites in host tissues from early stages of infection and show biological interactions among different genotypes and populations of T. cruzi.Graphical abstract
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research