Structure and mechanism of bacterial tripartite efflux pumps

Publication date: Available online 19 May 2018Source: Research in MicrobiologyAuthor(s): Arthur Neuberger, Dijun Du, Ben F. LuisiAbstractEfflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These tripartite machineries span both membranes and the periplasmic space, and they extrude from the bacterium chemically diverse toxic substrates. In this chapter, we summarise current understanding of the structural architecture, functionality, and regulation of tripartite multi-drug efflux assemblies.
Source: Research in Microbiology - Category: Microbiology Source Type: research