DNA methylation and gene expression of the chemokine (C-X-C motif) ligand 1 in patients with Deficit and Non-Deficit Schizophrenia

Deficit schizophrenia (DS) has been discovered more than two decades ago and is characterized by the presence of primary and persistent negative symptoms (Carpenter  et al., 1988). Over the years, emerging data has suggested that, DS differ from non-deficit schizophrenia (NDS) in terms of risk factors, premorbid functioning, disease course, neurobiological correlates and response to treatment (Kirkpatrick et al., 2001, 2008, 2014; Galderisi et al., 2009). To date, it has become clear that DS represent a separate disease entity of schizophrenia with respect to NDS (Carpenter et al., 1988; Blanchard et al., 2005; Ahmed et al, 2015; Yu et al., 2015).

Source: Psychiatry Research - July 4, 2018 Category: Psychiatry Authors: Chao Zhou, Jiu Chen, Xiaowei Tang, Xiaotang Feng, Miao Yu, Weiwei Sha, Xiang Wang, Xiaobin Zhang, Hongwei Yi, Xiangrong Zhang Source Type: research