Impaired cerebral oxygenation and exercise tolerance in patients with severe obstructive sleep apnea syndrome

Impaired cerebral blood flow and cerebrovascular reactivity to hypercapnia during wakefulness at rest as well as reduced exercise tolerance have been reported in severe obstructive sleep apnea (OSA) patients. Impaired cerebral oxygenation and hemodynamics can contribute to reduced exercise performance. We hypothesized that (i) OSA patients show impaired cerebrovascular response both during exercise and in response to hypercapnia together with reduced exercise tolerance and (ii) continuous positive airway pressure (CPAP) treatment improves these alterations in cerebral oxygenation.

Source: Sleep Medicine - July 4, 2018 Category: Sleep Medicine Authors: Mathieu Marillier, Mathieu Gruet, S ébastien Baillieul, Bernard Wuyam, Renaud Tamisier, Patrick Levy, Jean-Louis Pepin, Samuel Verges Tags: Original Article Source Type: research