The value of androgen receptor, cytokeratin 20, and cytokeratin 7 expression in differentiating basal cell carcinoma from trichoepithelioma

Background: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histological features with basal cell carcinoma (BCC). It is important to distinguish these neoplasms because they require different therapeutic planning. Many studies have addressed the use of immunohistochemistry to improve the differential diagnosis of these tumors. Evaluation of androgen receptor (AR), cytokeratin 20 (CK20), and CK7 expression may aid in distinguishing the two tumors. Materials and methods: Immunohistochemical expression of AR, CK20, and CK7 was studied in 30 cases of TE and BCC. Results: AR was expressed in 11 of 15 cases of BCC (73.3%) whereas it was not expressed in any of the cases of TE 0/15 (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research