The prognostic significance of vascular endothelial growth factor expression in Wilms’ tumor and its relevance to WT1 expression

Conclusion: VEGF expression appears to have no prognostic influence on Wilms’ tumor. WT1 expression, advanced tumor stage, and the high-risk pathological group are poor prognostic factors in Wilms’ tumor. The high expression of VEGF and WT1 and their significant positive correlation implicate them in tumorogenesis and further support the postulated regulatory influence of VEGF over WT1 expression. This points toward the potential role of targeted therapy in Wilms’ tumor.
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research