Tumor necrosis factor- α promotes hepatocellular carcinogenesis through the activation of hepatic progenitor cells

Hepatocellular carcinoma (HCC) is an inflammation-related disease. Tumor necrosis factor alpha (TNF- α) is an important inflammatory factor and it has been confirmed to promote tumor growth and poor prognosis of HCC. Hepatic progenitor cells (HPCs) are thought to play an important role in liver injury and repair, as well as tumorigenesis. Chronic inflammation influences HPCs activation as well as differentiation. However, the mechanism is still unclear. In our study, the rat liver cancer model was constructed by DEN treatment, TNFR2-Fc fusion protein variant (TNFR2-FcV) and TNF-α-/- rats were used to dectect the role of TNF-α in liver injury and tumorigenesis.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research