A novel chalcone derivative from Punica granatum peel inhibits LOX/COX enzyme activity

Publication date: Available online 3 July 2018 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): S. Sudheesh, K. Soumya, Jesna James The present study evaluates the Lipoxygenase (LOX) and cyclooxygenase (COX) inhibitory activity of a flavonoid isolated from Punica granatum peel. The molecular structure and chemical bonds were analyzed on the basis of different spectroscopic techniques. The chemical structure of the compound proves that it is a novel chalcone derivative. The isolated compound was elucidated as (2E)-3-(4-hydroxy-3-pentylphenyl)-1-(2-hydroxy-4,5-di((E)-prop-1-enyl)phenyl)prop-2-en-1-one. A prominent inhibition on LOX and COX was observed. The in vitro study indicates the potential of isolated compound to use as an anti-inflammatory agent.
Source: Beni Suef University Journal of Basic and Applied Sciences - Category: Science Source Type: research