IgA dominant glomerulonephritis with a membranoproliferative pattern of injury

IgA dominant membranoproliferative glomerulonephritis (MPGN) is a descriptive term for renal biopsies in which differential diagnoses of unusual IgA nephropathy (IgAN), infection-related GN, or other etiologies are considered. We sought to understand clinical and pathologic features of this finding. Native kidney biopsies with IgA dominant immune deposits and diffuse MPGN features without significant exudative features or subepithelial deposits were retrospectively reviewed. Two groups (n=27, 33 biopsies) were identified, patients with chronic liver disease and those without.

Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Nicole K. Andeen, J. Ashley Jefferson, Shreeram Akilesh, Charles E. Alpers, Mei Lin Bissonnette, Laura S. Finn, John Higgins, Donald C. Houghton, Neeraja Kambham, Alex Magil, Behzad Najafian, Roberto F. Nicosia, Megan L. Troxell, Kelly D. Smith Tags: Original Contributions Source Type: research