Simplification of first-line antibacterial regimen for complicated appendicitis in children is associated with better adherence to guidelines and reduced use of antibiotics

Acute appendicitis is a common surgical condition affecting 0.3 –0.4% of children, with a peak incidence between 8–13 years of age. The most common complications include perforation, peritonitis and abscess, found in 25–39% of cases [1]. Treatment of acute appendicitis usually relies on early surgery (appendectomy and, when necessary, management of complic ations) and a short course of antibiotics (4–7 days) [2], although highly selected patients with a well circumscribed focus of infection may be cured by antimicrobial therapy alone [3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research