A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy

Photodynamic therapy (PDT) is an effective treatment for actinic keratosis (AK), basal cell carcinoma (BCC) and Bowen ’s disease [1,2]. A pro-drug (generally 5-aminolaevulinic acid or methylaminolevulinate) of the photosensitiser protoporphyrin IX (PpIX) is applied to the skin in a cream base and with conventional hospital-based PDT, after an incubation period usually of 3 h, irradiation is undertaken using eit her red or blue light. The preferential uptake of PpIX in abnormal cells enables specific treatment of diseased tissue, whilst sparing normal skin.

Source: Photodiagnosis and Photodynamic Therapy - June 16, 2018 Category: Laser Surgery Authors: Paul O ’Mahoney, Neil Haigh, Kenny Wood, C. Tom A. Brown, Sally Ibbotson, Ewan Eadie Source Type: research