Early stage NSCLC — challenges to implementing ctDNA-based screening and MRD detection

Early stage NSCLC — challenges to implementing ctDNA-based screening and MRD detectionEarly stage NSCLC — challenges to implementing ctDNA-based screening and MRD detection, Published online: 03 July 2018; doi:10.1038/s41571-018-0058-3Liquid biopsy approaches hold great promise in early cancer diagnosis or minimal residual disease monitoring for cancer recurrence. Herein, the authors evaluate contemporary next-generation sequencing approaches to circulating tumour DNA detection in these contexts, with a focus on studies in patients with non-small-cell lung cancer. They discuss the feasibility of introducing these strategies into the clinic, highlighting the technical and analytical challenges, as well as possible solutions.

Source: Nature Clinical Practice Oncology - July 3, 2018 Category: Cancer & Oncology Authors: Christopher Abbosh Nicolai J. Birkbak Charles Swanton Source Type: research