Potential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibition
Conclusion:
We present a model of the neuromuscular junction confirming observed acetylcholine signaling data and suggesting that developing a countermeasure capable of reducing inhibitor binding, and not activator concentration, is the most important parameter for reducing organophosphate (OP) intoxication.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Richard ChapleauPeter RobinsonJohn SchlagerJeffery Gearhart Source Type: research