Integrin α5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway

In this study we found that miR-205 expression level is extremely low in basal mesenchymal-like highly migratory and invasive TNBC cells. Stably re-expressing miR-205 in TNBC cells significantly reduced their migration, invasion capability and cancer stem cell (CSC)-like property.

Source: Cancer Letters - July 2, 2018 Category: Cancer & Oncology Authors: Yajuan Xiao, Yunfei Li, Hua Tao, Brock Humphries, Aimin Li, Yiguo Jiang, Chengfeng Yang, Rongcheng Luo, Zhishan Wang Tags: Original Articles Source Type: research