ALA-PDT suppressing the cell growth by Akt-/Erk-mTOR-p70 s6k pathway in human SZ95 sebocytes in vitro

Acne vulgaris is an inflammatory disease of the pilosebaceous unit. Photodynamic therapy (PDT) with aminolevulinic acid (ALA) can significantly decrease the number of sebaceous glands via protoporphyrin IX (PpIX) which produces reactive oxygen species by reacting with oxygen, causing cell membrane damage and sebaceous cell apoptosis[1]. As a result, ALA-PDT has been used as an alternative treatment for acne vulgaris for nearly 20 years.

Source: Photodiagnosis and Photodynamic Therapy - July 2, 2018 Category: Laser Surgery Authors: Wenjie Liu, Qianqian Wang, Jiang Tuo, Yufeng Chang, Jiayi Ying, Min Jiang, Christos C. Zouboulis, Leihong Xiang Source Type: research