Inhibiting ABCG2 could potentially enhance the efficacy of Hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer

Photodynamic Therapy (PDT) involves the administration of a tumour-retaining photosensitiser (PS), followed by light administration to generate reactive oxygen species (ROS) that cause necrosis and apoptosis, depending on the type and concentration of PS, light dose and tissue sensitivity [1 –3]. Hypericin, a photoactive compound found in St. John’s Wort (Hypericum perforatum) [4], has attracted interest through its diverse range of medicinal applications, including PDT in pre-clinical cancer studies [5–12].

Source: Photodiagnosis and Photodynamic Therapy - July 2, 2018 Category: Laser Surgery Authors: M. Ibrahim Khot, Sarah L. Perry, Thomas Maisey, Gemma Armstrong, Helen Andrew, Thomas A. Hughes, Nikil Kapur, David G. Jayne Source Type: research