An Exciting Couple

Contraction of skeletal muscle is an exquisitely orchestrated process that has been studied at the molecular level for more than 80 years. Although the contractile protein machinery is understood in detail, excitation, contraction, and many muscle pathologies also require understanding the critical roles of membrane systems (Figure 1). Figure 1. Steps in skeletal muscle excitation, contraction and E-C coupling. Ach = acetylcholine; Ry = ryanodine; DHP = dihydropyridine The firing of motor nerves originating from the brain or spinal cord initiates a contraction. An action potential from a single

Source: Journal of Pediatric Ophthalmology and Strabismus - May 29, 2018 Category: Opthalmology Authors: Frederick M. Wang, MD Source Type: research