R éaction pseudo-multicomposants entre le glutaconate de diméthyle et des aldéhydes aromatiques induite par le bromure de phénylzinc : accès domino à des dihydropyranones 2,3,5-trisubstituées

Publication date: Available online 28 June 2018 Source:Comptes Rendus Chimie Author(s): Erwan Le Gall, Marc Presset, Éric Léonel, Pascal Retailleau Phenylzinc bromide enables a pseudo three-component reaction of methyl glutaconate and aromatic aldehydes. Unsaturated trisubstituted δ-valerolactones (dihydropyranones) are obtained in fair to good yields by an aldol/aldol/elimination/lactonization domino process that allows the formation of four new bonds in a single step. A putative reaction mechanism is proposed. Graphical abstract

Source: Comptes Rendus Chimie - June 29, 2018 Category: Chemistry Source Type: research