Are low-molecular-weight heparins safe and effective in children? A systematic review

The incidence of venous thromboembolism (VTE) in children is rising. Hence, there is an increasing off-label use of low-molecular-weight heparin (LMWH). There is little data about therapeutic and prophylactic LWMH dosages, and their safety and efficacy. This systematic review provided an oversight of the therapeutic and prophylactic dosages of LMWH required to reach therapeutic and prophylactic target ranges. Furthermore, the safety and efficacy of LMWH, in terms of bleeding complications, achieving therapeutic and prophylactic anti-factor Xa levels, development of (recurrent) VTE and cloth resolution were reviewed.

Source: Blood Reviews - June 27, 2018 Category: Hematology Authors: Irene L.M. Klaassen, Jeanine J. Sol, Monique H. Suijker, K. Fijnvandraat, Marianne D. van de Wetering, C. Heleen van Ommen Tags: Review Source Type: research