Colistin resistance in carbapenemase-producing Klebsiella pneumoniae bloodstream isolates: evolution over 15 years and temporal association with colistin use by time series analysis

Carbapenemase-producing Klebsiella pneumoniae (CP-Kp) has been established as an important nosocomial pathogen in many geographic areas, causing serious infections associated with increased morbidity and mortality [1-4]. The carbapenemases commonly encountered among CP-Kp isolates are the KPC variants, the zinc-dependent metallo- β-lactamases (VIM, IMP, and NDM types) and the OXA-48 enzymes that inactivate almost all clinically available β-lactams.[4] Virtually all CP-Kp isolates exhibit extensive drug resistance phenotypes and frequently polymyxins (colistin, polymyxin B), tigecycline, and fosfomycin are the only agents w ith in vitro activity against these pathogens [5-8].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research