Integrons and insertion sequence common region 1 (ISCR1) of carbapenem-non-susceptible Gram-negative bacilli in fecal specimens from 5,000 patients in southern China

Integrons are bacterial genetic elements composed of two conserved regions, a 3 ′-conserved segment (3′-CS) and a 5′-conserved segment (5′-CS) [1]. They capture and express genes within an internal variable region containing mobile gene cassettes that encode antimicrobial resistance determinants. Their mechanisms and mobility, such as the excision and integration of gen e cassettes, are well established [2]. To date, five general classes of integrons have been identified and distinguished. Classes 1–3 are known multidrug-resistant integrons, and may ultimately contribute to the unleashing of ‘superbugs [2, 3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research