Pancreatic cancer-derived exosomes suppress the production of GIP and GLP-1 from STC-1  cells in vitro by down-regulating the PCSK1/3

One hallmark of pancreatic cancer (PC) is the high prevalence of pancreatic cancer-associated diabetes mellitus (PC-DM), but the mechanisms remain to be elucidated. Patients with PC who are diagnosed with new-onset diabetes/prediabetes have recently been shown to display significantly lower levels of glucose-dependent insulinotropic peptide (GIP) secreted mainly by enteroendocrine cells. We hypothesized that PC-derived exosomes are responsible for the decreased levels of incretins in patients with PC-DM.

Source: Cancer Letters - May 22, 2018 Category: Cancer & Oncology Authors: Yuefeng Zhang, Shifei Huang, Pengping Li, Qing Chen, Yongzhou Li, Yizhao Zhou, Lantian Wang, Muxing Kang, Bo Zhang, Bin Yang, Xin Dong, Yulian Wu Tags: Original Articles Source Type: research