Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology

Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) has been identified as a cancer-specific transcript in various solid cancers, including colorectal cancer. Given its excellent cancer-specific expression profile, we hypothesized that Ct-OATP1B3 could represent a promising target for cancer-specific expression of the suicide gene, herpes simplex virus 1 thymidine kinase (HSV-tk), via a spliceosome-mediated RNA trans-splicing (SMaRT) approach. SMaRT technology used to recombine two RNA molecules to generate a chimeric transcript.

Source: Cancer Letters - June 27, 2018 Category: Cancer & Oncology Authors: Yuchen Sun, Josefina Pi ñón Hofbauer, Manami Harada, Katharina Wöss, Ulrich Koller, Hanae Morio, Anna Stierschneider, Keita Kitamura, Mari Hashimoto, Kan Chiba, Hidetaka Akita, Naohiko Anzai, Julia Reichelt, Johann W. Bauer, Christina Guttmann-Gruber, Tags: Original Articles Source Type: research