FIRST REPORT OF EXTREMELY DRUG RESISTANT PROTEUS MIRABILIS ISOLATE CARRYING PLASMID-MEDIATED blaNDM-1 IN A TUNISIAN INTENSIVE CARE UNIT

The rapid emergence of antibiotic resistance among Gram-negative bacilli is a serious threat to the management of infectious diseases. β-lactam antibiotics are the most frequently used antimicrobials for empirical therapy. Production of β-lactamases is one of the strategies adopted by bacteria to develop resistance to the β-lactam class of antibiotics [1]. P. mirabilis is an emerging cause of nosocomial infections, particularly of wounds and the urinary tract. The infections caused by this enterobacterial species are difficult to treat because of acquisition of various resistance mechanisms, such as Extended spectrum β-lactamases (ESBLs) or AmpC β-lactamases [2].

Source: International Journal of Antimicrobial Agents - June 26, 2018 Category: Drugs & Pharmacology Authors: Kanzari Lamia, Ferjani Sana, Saidani Mabrouka, Hamzaoui Zeineb, Jendoubi Ali, Harbaoui Sarra, Ferjani Asma, Rehaiem Amel, Boutiba Ben Boubaker Ilhem, Slim Amine Tags: Themed Issue: Recent Advances in Antimicrobial and Bacterial Resistance Source Type: research