17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage [Clinical Sciences]

Background and Purpose—Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.Methods—We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-assisted technique. After quality control and imputation, 7 million genetic variants were available for association testing with ICH volume, which was performed separately in lobar and nonlobar ICH cases using linear regression. Signals with P

Source: Stroke - June 25, 2018 Category: Neurology Authors: Sandro Marini, William J. Devan, Farid Radmanesh, Laura Miyares, Timothy Poterba, Bȷorn M. Hansen, Bo Norrving, Jordi Jimenez–Conde, Eva Giralt–Steinhauer, Roberto Elosua, Elisa Cuadrado–Godia, Carolina Soriano, Jaume Roquer, Chri Tags: Genetics, Computerized Tomography (CT), Quality and Outcomes, Intracranial Hemorrhage Original Contributions Source Type: research