Genomic structures of dysplastic nodule and concurrent hepatocellular carcinoma

The objective of this study was to identify genomic alterations of HGDN and its difference from HCC that may drive HGDN progression to HCC. We analyzed 16 regions of paired HGDN and HCC from 6 patients using whole-exome sequencing to find somatic mutation and copy number alteration (CNA) profiles of HGDN and HCC.

Source: Human Pathology - June 24, 2018 Category: Pathology Authors: Minho Lee, Kyung Kim, Shinn Young Kim, Seung-Hyun Jung, Jonghwan Yoon, Min Sung Kim, Hyeon-Chun Park, Eun Sun Jung, Yeun-Jun Chung, Sug Hyung Lee Tags: Original Contributions Source Type: research